The incident happened between 6pm on Wednesday 22 November and 6am on Thursday 23 November 2017 at The Yard on Willand Road, Cullompton.
Thieves entered a yard and loaded the 40ft static caravan on to a flat trailer and removed it from the yard.
The victim, a local woman, was not present at the time of the offence and is now without a home. Pictures of the park home are attached. The serial number is SA11.049221E.
PC Marie Gorfin said: “The home would have to had to been taken by a specific low loader trailer that is capable of taking a caravan of this size and by someone that knew what they were doing.
“This is a very high value and emotive crime as victim is now homeless and clearly distraught.
“We are urging anyone with information to come forward to police by emailing us via firstname.lastname@example.org or by calling 101 quoting CR/102371/17.”
You can also give information anonymously via Crimestoppers on 0800 555 111.